LONDON, Great Britain - Unseeded Italian Camila Giorgi marched into uncharted waters at Wimbledon on Monday, as the 26-year-old reached her first Grand Slam quarterfinal with a 6-3, 6-4 victory over Russia's Ekaterina Makarova. 

Having first reached the second week of a major at Wimbledon six years ago, the Italian was 0-2 in her career in fourth round matches at majors, having never won a set. 

However, the World No.52 booked a quarterfinal meeting with No.25 seed Serena Williams - who defeated qualifier Evgeniya Rodina on Centre Court later in the day - thanks to a commanding performance over 89 minutes. 

"I'm not surprised. I always work to be here. In the last two years I was always with an injury sometimes, having many problems physically. I think this year I have more continuity. It's for that I can make here."

- Camila Giorgi on reaching her first Grand Slam quarterfinal.

Giorgi needed four match points to seal her place in the last eight, as she saved a break point after firing a first-ball forehand winner off a perfectly placed serve out wide, and sealed victory with a smash at the net - her ninth point won there in 12 trips overall.

"It was a very good match, like I say, very consistent. It was a good match," the Italian added. "I think I'm playing better than the start of the season. I think I did a great matches, so I hope to keep going."

Behind 21 winners, five aces and three breaks of serve, the Italian never allowed the Russian a lead in the match as she broke first in each set. 

"I wanted to play a bit better today, but also, Giorgi, she played very good, very aggressive. She didn't let me to play my game. She was a little bit every time earlier with the winner, earlier with the aggressive shot," Makarova said in defeat.

"I was a little bit, also maybe a bit nervous at the beginning - my serve it didn't go as good as I wanted and not a lot of first serves and she broke me. I was fighting and trying to came back until the end, but, yeah, today she was a bit better."

The Italian hasn't won a set in three career meetings against the 23-time major champion, and Tuesday's meeting will be their second at a Grand Slam. Williams won a 6-4, 7-5 encouter in the first round of the Australian Open in 2016 en route to the final. 

"I think I'm focused on my game. I will be focused on my game, and we'll see," the Italian said. "I mean, like I say, I'm playing a very good tennis, so I think on myself and that's all."